Agarwal, A., Gupta, N.D., Jain, A.

Objective
Polypeptide growth factors of platelet rich fibrin (PRF) have the potential to regenerate periodontal tissues. The osteoinductive property of demineralised freeze-dried bone allograft (DFDBA) has been successfully utilised in periodontal regeneration. The aim of the present randomised, split mouth clinical trial was to determine the additive effects of PRF with a DFDBA in the treatment of human intrabony periodontal defects.

Materials and methods
Sixty interproximal infrabony defects in 30 healthy, non-smoker patients diagnosed with chronic periodontitis were randomly assigned to the PRF/DFDBA group or the DFDBA/saline group. Clinical (pocket depth [PD], clinical attachment level [CAL] and gingival recession [REC]) and radiographic (bone fill, defect resolution and alveolar crest resorption) measurements were made at baseline and at a 12-month evaluation.

Results
Compared with baseline, 12-month results indicated that both treatment modalities resulted in significant changes in all clinical and radiographic parameters. However, the PRF/DFDBA group exhibited statistically significantly greater changes compared with the DFDBA/saline group in PD (4.15 ± 0.84 vs. 3.60 ± 0.51mm), CAL (3.73 ± 0.74 vs. 2.61 ± 0.68mm), REC (0.47 ± 0.56 vs. 1.00 ± 0.61mm), bone fill (3.50 ± 0.67 vs. 2.49 ± 0.64mm) and defect resolution (3.73 ± 0.63 vs. 2.75 ± 0.57mm).

Conclusion
Observations indicate that a combination of PRF and DFDBA is more effective than DFDBA with saline for the treatment of infrabony periodontal defects.

Acta Odontol Scand 2016; 74 (1): 36-43.