Midazolam and drug–drug interactions in dental conscious sedation

Abstract

Careful prescribing is paramount in clinical practice. Potential drug–drug interactions need to be considered. Midazolam is the drug of choice for the purpose of IV sedation.To ensure safe clinical practice, the patient’s current medications need to be recorded.

Clinical relevance
An update on the drug interactions relating to midazolam are worthy of scrutiny as its use becomes more commonplace in clinical practice.

Objective
The dentist should understand the possible implications for drug interactions when sedating patients using midazolam.

Dr Damian Broderick
BA BDentSc MB BAO BCh FFD (OSOM) Dip Con Sed
National Maxillofacial Unit, St James’s Hospital, Dublin 8

Dr Mary Clarke
MDentCh FFD Dip Con Sed
Specialist in Oral Surgery/Lecturer in Conscious Sedation
Department of Oral and Maxillofacial Surgery, Dublin Dental University Hospital

Prof. Leo Stassen
FRCS(Ed) FDSRCS MA FTCD FSEM(UK) FFDRCSI FICD
Consultant Oral and Maxillofacial Surgeon, Dublin Dental University Hospital, National Maxillofacial Unit, St James’s Hospital, Dublin 8

Corresponding author: Prof. Leo Stassen
National Maxillofacial Unit, Dublin Dental School and Hospital, Lincoln Place, Dublin 2.
E: leo.stassen@dental.tcd.ie